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ORIGINAL HYPOTHESIS
Year : 2012  |  Volume : 3  |  Issue : 3  |  Page : 95-98

Does Gonadotropin Releasing Hormone Agonists plus add-back therapy bring an aurora to orthodontic treatment?


1 Department of Oral and Maxillofacial Surgery, Centre of Craniofacial Orthodontics Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key Laboratory of Stomatology, Shanghai, PR China
2 Department of Obstetrics and Gynecology, Hospital of Obstetrics and Gynecology, Fu Dan University, Shanghai, PR China

Correspondence Address:
Fang Bing
Department of Oral and Maxillofacial Surgery, Centre of Craniofacial Orthodontics, Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai Key, Laboratory of Stomatology, Shanghai
PR China
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Source of Support: The work supported by the National natural science Foundation of China (30901698, 10972142) and Science and Technology Commission of Shanghai (08411961600), Conflict of Interest: None


DOI: 10.4103/2155-8213.103915

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Introduction: Obviously, long therapy time of orthodontic treatment and a number of its adverse effects, such as pain, root resorption, enamel demineralization, periodontal disease, are the main reasons of complaints from patients. It is the first thing for an orthodontist to shorten the period of treatment and decrease the complications of orthodontic treatment as much as possible. The Hypothesis: We hypothesis Gonadotropin Releasing Hormone Agonists (GnRHa) and add-back therapy can create the "therapeutic window", namely, the appropriate estrogen level and assuage the adverse effects of estrogen deficiency which should be avoided as much as possible. Evaluation of the Hypothesis: It is generally acknowledged that estrogen has direct regulating role in bone metabolism by acting on osteoblasts and osteoclasts. Estrogen deficiency can increase the rate of orthodontic tooth movement and also bring about some adverse effects. The appropriate estrogen level, which we call the "therapeutic window" in orthodontic treatment, can speed up the orthodontic tooth movement and eliminate the adverse effects as far as possible. GnRHa can be the maker of estrogen deficiency; meanwhile, add-back therapy can remove the adverse effects by estrogen deficiency. So, we believe that GnRHa plus add-back therapy could be a new adjuvant method of orthodontic treatment and be good for orthodontists and patients.


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