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ORIGINAL HYPOTHESIS
Year : 2013  |  Volume : 4  |  Issue : 2  |  Page : 53-54

Mutanase-containing chewing gum: A new potential approach for prevention of dental caries


1 Founder and Managing Editor of Dental Hypotheses, Isfahan, Iran
2 Department of Periodontology, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Correspondence Address:
Mohamadreza Abrishami
Department of Periodontology, Shahid Beheshti University of Medical Sciences, Tehran
Iran
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2155-8213.113010

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Introduction: Study on the effect of topically applied mutanase on plaque formation and caries in rats showed strong inhibition of dental caries. Furthermore, it has been shown that the presence of mutanase in dental plaque may affect the synthesis and structure of sticky, extracellular glucans. The Hypothesis: Mutanase can be easily added to gum base. After chewing of mutanase-containing chewing gum, the enzyme will be released into the oral cavity. Mutanase will hydrolyze sticky, extracellular glucans, e.g., mutan inhibiting cariogenic bacteria to cohere/adhere and form plaque. Evaluation of the Hypothesis: The main challenge with this hypothesis is the source of mutanase. It can be obtained from Paenibacillus sp. MP-1 or Trichoderma harzianum F-340. Directly compressible medicated chewing gum bases can be used to avoid inactivation of mutanase during the manufacturing process.


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