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SYSTEMATIC REVIEW
Year : 2015  |  Volume : 6  |  Issue : 4  |  Page : 134-140

Implications and applications of systematic reviews for evidence-based dentistry and comparative effectiveness research: A sample study on antibiotics for oro-facial cellulitis treatment


1 Student, Division of Oral Biology and Medicine, Section of Oral Biology, UCLA School of Dentistry, Los Angeles, California, USA
2 Student, Division of Oral Biology and Medicine, Section of Oral Biology; Evidence-Based Decision Practice-Based Research Network, UCLA School of Dentistry, Los Angeles, California, USA

Correspondence Address:
Francesco Chiappelli
School of Dentistry, Division of Oral Biology and Medicine, UCLA Center for the Health Sciences 63-090, 10833 Le Conte Avenue, Los Angeles - 90095-1668, California
USA
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Source of Support: None, Conflict of Interest: None


DOI: 10.4103/2155-8213.170639

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Introduction: Comparative effectiveness and efficacy research for analysis and practice (CEERAP) was performed to assess the effects of penicillin-based versus erythromycin-based antibiotic treatments in patients with skin and soft tissue infections (SSTIs) including cellulitis, impetigo, and erysipelas. Because SSTIs, especially orofacial cellulitis, are volatile infectious diseases of a life-threatening nature, research on the most efficacious remedies is necessary. Methods: The stringent bibliome yielded three systematic reviews, which were examined for quality of research synthesis protocol and clinical relevance. Results: The sample size of three, rendered the statistical analyses and cumulative meta-analysis problematic. Conclusion: The systematic review outlined here should aid in increasing clinical awareness, improving patient health literacy, and promoting consensus of the best evidence base (BEB) to mitigate the threat of sepsis and potential death caused by cellulitis infections.


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