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| ORIGINAL HYPOTHESIS |
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| Year : 2013 | Volume
: 4
| Issue : 2 | Page : 50-52 |
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Local use of iontophoresis with traditional Chinese herbal medicine, e.g., Gu-Sui-Bu (Rhizoma Drynariae) may accelerate orthodontic tooth movement
Yongming Li
Department of Orthodontics, School of Stomatology, Fourth Military Medical University, China
| Date of Web Publication | 5-Jun-2013 |
Correspondence Address:
Yongming Li
Department of Orthodontics, School of Stomatology, The Fourth Military Medical University, 145 West Changle Road, 710032, Xi'an, Shaanxi Province
China
 Source of Support: None, Conflict of Interest: None  | Check |
DOI: 10.4103/2155-8213.113008
Introduction: Mechanical force is not the only means to cause tooth movement, but just one kind of stimuli for it. Biological stimuli, with potential of accelerating alveolar bone remodeling, other than mechanical force, have been attracted by orthodontists who are combating prolonged treatment duration. It has been approved that some traditional Chinese medicines, such as Gu-Sui-Bu (Rhizoma Drynaria), affect the process of bone remodeling. The Hypothesis: We make the hypothesis that local use of iontophoresis with Gu-Sui-Bu (Rhizoma Drynaria) as a non-invasive and safe drug delivery system with no trauma, risk of infection or damage to patients is a new potential approach for accelerating orthodontic tooth movement, and shorten the orthodontic treatment time. Evaluation of the Hypothesis: Gu-Sui-Bu is effective at inducing bone remodeling, and iontophoresis as a non-invasive technique for drug delivery, is suitable for the transmission of some traditional Chinese herbal medicines into periodontal tissues. Keywords: Chinese herbal medicine, Gu-Sui-Bu (Rhizoma Drynariae), iontophoresis, orthodontic tooth movement
How to cite this article:
Li Y. Local use of iontophoresis with traditional Chinese herbal medicine, e.g., Gu-Sui-Bu (Rhizoma Drynariae) may accelerate orthodontic tooth movement. Dent Hypotheses 2013;4:50-2 |
How to cite this URL:
Li Y. Local use of iontophoresis with traditional Chinese herbal medicine, e.g., Gu-Sui-Bu (Rhizoma Drynariae) may accelerate orthodontic tooth movement. Dent Hypotheses [serial online] 2013 [cited 2023 Mar 21];4:50-2. Available from: http://www.dentalhypotheses.com/text.asp?2013/4/2/50/113008 |
| Introduction | |  |
Orthodontic tooth movement resulted from the effects of mechanical force on the tooth, which was characterized by the remodeling of the alveolar bone and soft-tissues surrounding the tooth. Most orthodontic devices presently in use apply mechanical force to the tooth or alveolar bone and are thus expected to control tooth movement. However, contemporary researches suggest that mechanical force is not the only means to cause tooth movement, but just one kind of stimuli for it. Biological stimuli, with potential of accelerating alveolar bone remodeling, other than mechanical force, have been attracted by orthodontists who are combating prolonged treatment duration. Various attempts, including pharmaceutical trial and physical stimulation, have been made to shorten the time necessary for orthodontic tooth movement. However, no matter local injection or systemic administration of medicines such as vitamin D, [1] prostaglandins [2] and epidermal growth factor, [3] these pharmaceutical strategies have such drawbacks as non-specific, undesirable effects, invasive, and increased risk of side-effects on other systems of the human body, which limit their clinical applications. Traditional Chinese medicine is a treasure house, which has been extensively used, apparently safely and effectively, to treat various bone diseases for more than a millennium in Asian countries, especially in China. [4] In the Western countries, medicinal herbs are becoming increasingly popular and important in the public and scientific communities. It has been shown that some traditional Chinese medicines, such as Gu-Sui-Bu (Rhizoma Drynariae), affect the process of bone remodeling, [5] and iontophoresis as a non-invasive technique for drug delivery may be suitable for the transmission of some traditional Chinese herbal medicines into periodontal tissues. [6]
| The Hypothesis | | |
Since, some traditional Chinese medicines, such as Gu-Sui-Bu (Rhizoma Drynariae), affect the process of bone remodeling, [5] and orthodontic tooth movement is related to the response to applied mechanical forces that cause remodeling of periodontal tissues, especially alveolar bone, then we can make the hypothesis that local use iontophoresis with traditional Chinese herbal medicine as a non-invasive and safe drug delivery system with no trauma, risk of infection or damage to patients is therefore a new potential approach for accelerating orthodontic tooth movement, and shorten the orthodontic treatment time, but further studies will be needed to explore the precise dosage, duration and frequency of Gu-Sui-Bu in orthodontic treatment fields.
| Evaluation of the Hypothesis | | |
Effect of traditional Chinese medicines on bone remodeling
Traditional Chinese medicines have been used in the Chinese population for the treatment of bone diseases and to promote bone healing for thousands of years. Some traditional Chinese medicines have shown therapeutic effects on fracture healing in clinical and animal studies [6],[7],[8],[9] J.Smith, was commonly used to manage disorders of orthopedics and had been claimed to have therapeutic effects on bone healing. [5] Ma et al, [10] found that Gu-Sui-Bu injection significantly promoted calcification of the cultivated chick embryo bone primordium, increased alkaline phosphatase (ALP) activity in the cultivated tissue, and accelerated synthesis of proteoglycan. Liu et al, [11] has shown that
Gu-Sui-Bu has an antioxidant effect on rat osteoblasts from hydrogen peroxide-induced death and may promote bone recovery under similar pathologic conditions. Sun et al, [5] investigated the biochemical effects of Gu-Sui-Bu on the bone cells culture. The results demonstrated that this traditional Chinese medicine has potential effects on the bone cells culture. One of the major effects of Gu-Sui-Bu on the bone cells is probably mediated by its effect on the osteclasts activities. Chen et al, [12] reported that Gu-Sui-Bu could reinforce osteoblastic function and activity, contributing to new bone formation. These findings support the idea that Gu-Sui-Bu is effective at inducing bone remodeling.
Iontophoretic drug delivery
Iontophoresis is a method that uses an electrical current to increase the penetration of drugs into the body for therapeutic purposes. As a non-invasive technique for drug delivery, iontophoresis has been long used to deliver various chemicals and drugs into human tissues. Local use of iontophoresis indicated multiple applications in dentistry, dermatology, ophthalmology, and physical medicine. [6],[13],[14] It may also be suitable for the transmission of some traditional Chinese herbal medicines into periodontal tissues, including alveolar bone.
| Conclusion | | |
In addition to other hypotheses regarding acceleration of orthodontic tooth movement, [15],[16],[17],[18] we hypothesize that local use iontophoresis with some traditional Chinese herbal medicine, e.g., Gu-Sui-Bu (Rhizoma Drynariae) in proper dosage, duration and frequency as a non-invasive and safe drug delivery system with no trauma, risk of infection or damage to the patients will be a new potential approach which may accelerate orthodontic tooth movement, and shorten the orthodontic treatment time.
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