Dental Hypotheses

ORIGINAL HYPOTHESIS
Year
: 2015  |  Volume : 6  |  Issue : 1  |  Page : 10--13

Osterix combined with gene-activated matrix: A potential integrated strategy for achieving cementum regeneration


Rubing Liu1, Zhengguo Cao2 
1 Department of Periodontology, The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST KLOS) and Key Laboratory for Oral Biomedical Engineering of Ministry of Education; Department of Periodontology, the Affiliated Hospital of Stomatology, College of Medicine, Zhejiang University, Hangzhou, China
2 Department of Periodontology, The State Key Laboratory Breeding Base of Basic Science of Stomatology (Hubei-MOST KLOS) and Key Laboratory for Oral Biomedical Engineering of Ministry of Education; Department of Periodontology, School and Hospital of Stomatology, Wuhan University, Wuhan, China

Correspondence Address:
Zhengguo Cao
Department of Periodontology, School and Hospital of Stomatology, Wuhan University, Wuhan
China

Introduction: Human periodontitis is the most common infectious disease that results in the destruction of periodontal supporting tissues including the root cementum. Currently cementum regeneration, as a vital event, is considered as a gold standard of successful periodontal tissue reconstruction. Nevertheless, one of the important requirements of cementum reestablishment is the recruitment and differentiation of pre-cementoblasts into functional cementoblasts, which requires effective regulator factors. Recently, Osterix (Osx) is known to be a key transcriptional factor essential for osteogenesis and especially for cementogenesis. Although there are various interesting approaches involving tissue engineering, gene-activated matrix (GAM) is one of the most promising approaches to achieve reliable restoration of the periodontium. The Hypothesis: Based on the recent advances in understanding the mechanisms of Osx in cementum development and formation, we hypothesize that Osx plays a critical role in periodontal regeneration and Osx combined with GAM may be an effective strategy for the regeneration of cementum. Evaluation of the Hypothesis: Osx combined with GAM could pave the way for the development of new tissue engineering procedures and have the potential to play a pivotal role in cementum regeneration, eventually increasing the predictability of periodontal tissue regeneration.


How to cite this article:
Liu R, Cao Z. Osterix combined with gene-activated matrix: A potential integrated strategy for achieving cementum regeneration.Dent Hypotheses 2015;6:10-13


How to cite this URL:
Liu R, Cao Z. Osterix combined with gene-activated matrix: A potential integrated strategy for achieving cementum regeneration. Dent Hypotheses [serial online] 2015 [cited 2021 Mar 2 ];6:10-13
Available from: http://www.dentalhypotheses.com/article.asp?issn=2155-8213;year=2015;volume=6;issue=1;spage=10;epage=13;aulast=Liu;type=0